A prospective, observational study to evaluate adverse drug reactions in patients with COVID-19 treated with remdesivir or hydroxychloroquine: a preliminary report.
Identifieur interne : 000763 ( Main/Exploration ); précédent : 000762; suivant : 000764A prospective, observational study to evaluate adverse drug reactions in patients with COVID-19 treated with remdesivir or hydroxychloroquine: a preliminary report.
Auteurs : Fátima Falcão [Portugal] ; Erica Viegas [Portugal] ; Ines Carmo [Portugal] ; Joana Soares [Portugal] ; Margarida Falcao [Portugal] ; Mariana Solano [Portugal] ; Patricia Cavaco [Portugal] ; Dina Mendes [Portugal] ; João Rijo [Portugal] ; Pedro Povoa [Portugal] ; Antonio Pais Martins [Portugal] ; Eduarda Carmo [Portugal] ; Kamal Mansinho [Portugal] ; Candida Fonseca [Portugal] ; Luis Campos [Portugal] ; Ant Nio Carvalho [Portugal] ; Ana Mirco [Portugal] ; Helena Farinha [Portugal] ; Isabel Aldir [Portugal] ; José Correia [Portugal]Source :
- European journal of hospital pharmacy : science and practice [ 2047-9956 ] ; 2021.
Abstract
OBJECTIVES
Since the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pressure to minimise its impact on public health has led to the implementation of different therapeutic strategies, the efficacy of which for the treatment of coronavirus disease 2019 (COVID-19) was unknown at the time. Remdesivir (REM) was granted its first conditional marketing authorisation in the EU in June 2020. The European Medicines Agency (EMA) and local health authorities all across the EU have since strongly recommended the implementation of pharmacovigilance activities aimed at further evaluating the safety of this new drug. The objective of this study was to evaluate adverse drug reactions (ADRs) attributed to either REM or hydroxychloroquine (HCQ) in patients hospitalised for COVID-19 in Centro Hospitalar de Lisboa Ocidental, a Portuguese hospital centre based in Lisbon. We present the preliminary results reporting plausible adverse effects of either HCQ or REM.
METHODS
An observational cohort study was carried out between 16 March and 15 August 2020. Participants were divided into two cohorts: those prescribed an HCQ regimen, and those prescribed REM. Suspected ADRs were identified using an active monitoring model and reported to the Portuguese Pharmacovigilance System through its online notification tool. The ADR cumulative incidence was compared between the two cohorts.
RESULTS
The study included 149 patients, of whom 101 were treated with HCQ and the remaining 48 with REM. The baseline characteristics were similar between the two cohorts. A total of 102 ADRs were identified during the study period, with a greater incidence in the HCQ cohort compared with the REM cohort (47.5% vs 12.5%; p<0.001). Causality was assessed in 81 ADRs, all of which were considered possible.
CONCLUSIONS
Real-world data are crucial to further establish the safety profile for REM. HCQ is no longer recommended for the treatment of COVID-19.
DOI: 10.1136/ejhpharm-2020-002613
PubMed: 33452110
PubMed Central: PMC7813046
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A prospective, observational study to evaluate adverse drug reactions in patients with COVID-19 treated with remdesivir or hydroxychloroquine: a preliminary report.</title><author><name sortKey="Falcao, Fatima" sort="Falcao, Fatima" uniqKey="Falcao F" first="Fátima" last="Falcão">Fátima Falcão</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal mffalcao@chlo.min-saude.pt.</nlm:affiliation><country wicri:rule="url">Portugal</country><wicri:regionArea>Pharmacy, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Viegas, Erica" sort="Viegas, Erica" uniqKey="Viegas E" first="Erica" last="Viegas">Erica Viegas</name><affiliation wicri:level="1"><nlm:affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Carmo, Ines" sort="Carmo, Ines" uniqKey="Carmo I" first="Ines" last="Carmo">Ines Carmo</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Soares, Joana" sort="Soares, Joana" uniqKey="Soares J" first="Joana" last="Soares">Joana Soares</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Falcao, Margarida" sort="Falcao, Margarida" uniqKey="Falcao M" first="Margarida" last="Falcao">Margarida Falcao</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Solano, Mariana" sort="Solano, Mariana" uniqKey="Solano M" first="Mariana" last="Solano">Mariana Solano</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Cavaco, Patricia" sort="Cavaco, Patricia" uniqKey="Cavaco P" first="Patricia" last="Cavaco">Patricia Cavaco</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Mendes, Dina" sort="Mendes, Dina" uniqKey="Mendes D" first="Dina" last="Mendes">Dina Mendes</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Rijo, Joao" sort="Rijo, Joao" uniqKey="Rijo J" first="João" last="Rijo">João Rijo</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Povoa, Pedro" sort="Povoa, Pedro" uniqKey="Povoa P" first="Pedro" last="Povoa">Pedro Povoa</name><affiliation wicri:level="1"><nlm:affiliation>Polyvalent Intensive Care Unit, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Polyvalent Intensive Care Unit, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Pais Martins, Antonio" sort="Pais Martins, Antonio" uniqKey="Pais Martins A" first="Antonio" last="Pais Martins">Antonio Pais Martins</name><affiliation wicri:level="1"><nlm:affiliation>Surgical Intensive Care Unit. Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Surgical Intensive Care Unit. Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Carmo, Eduarda" sort="Carmo, Eduarda" uniqKey="Carmo E" first="Eduarda" last="Carmo">Eduarda Carmo</name><affiliation wicri:level="1"><nlm:affiliation>Polyvalent Intensive Care Unit. Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Polyvalent Intensive Care Unit. Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Mansinho, Kamal" sort="Mansinho, Kamal" uniqKey="Mansinho K" first="Kamal" last="Mansinho">Kamal Mansinho</name><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Fonseca, Candida" sort="Fonseca, Candida" uniqKey="Fonseca C" first="Candida" last="Fonseca">Candida Fonseca</name><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Campos, Luis" sort="Campos, Luis" uniqKey="Campos L" first="Luis" last="Campos">Luis Campos</name><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Carvalho, Ant Nio" sort="Carvalho, Ant Nio" uniqKey="Carvalho A" first="Ant Nio" last="Carvalho">Ant Nio Carvalho</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Mirco, Ana" sort="Mirco, Ana" uniqKey="Mirco A" first="Ana" last="Mirco">Ana Mirco</name><affiliation wicri:level="1"><nlm:affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Farinha, Helena" sort="Farinha, Helena" uniqKey="Farinha H" first="Helena" last="Farinha">Helena Farinha</name><affiliation wicri:level="1"><nlm:affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Aldir, Isabel" sort="Aldir, Isabel" uniqKey="Aldir I" first="Isabel" last="Aldir">Isabel Aldir</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Correia, Jose" sort="Correia, Jose" uniqKey="Correia J" first="José" last="Correia">José Correia</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33452110</idno><idno type="pmid">33452110</idno><idno type="doi">10.1136/ejhpharm-2020-002613</idno><idno type="pmc">PMC7813046</idno><idno type="wicri:Area/Main/Corpus">000477</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000477</idno><idno type="wicri:Area/Main/Curation">000477</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000477</idno><idno type="wicri:Area/Main/Exploration">000477</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A prospective, observational study to evaluate adverse drug reactions in patients with COVID-19 treated with remdesivir or hydroxychloroquine: a preliminary report.</title><author><name sortKey="Falcao, Fatima" sort="Falcao, Fatima" uniqKey="Falcao F" first="Fátima" last="Falcão">Fátima Falcão</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal mffalcao@chlo.min-saude.pt.</nlm:affiliation><country wicri:rule="url">Portugal</country><wicri:regionArea>Pharmacy, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Viegas, Erica" sort="Viegas, Erica" uniqKey="Viegas E" first="Erica" last="Viegas">Erica Viegas</name><affiliation wicri:level="1"><nlm:affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Carmo, Ines" sort="Carmo, Ines" uniqKey="Carmo I" first="Ines" last="Carmo">Ines Carmo</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Soares, Joana" sort="Soares, Joana" uniqKey="Soares J" first="Joana" last="Soares">Joana Soares</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Falcao, Margarida" sort="Falcao, Margarida" uniqKey="Falcao M" first="Margarida" last="Falcao">Margarida Falcao</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Solano, Mariana" sort="Solano, Mariana" uniqKey="Solano M" first="Mariana" last="Solano">Mariana Solano</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Cavaco, Patricia" sort="Cavaco, Patricia" uniqKey="Cavaco P" first="Patricia" last="Cavaco">Patricia Cavaco</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Mendes, Dina" sort="Mendes, Dina" uniqKey="Mendes D" first="Dina" last="Mendes">Dina Mendes</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Rijo, Joao" sort="Rijo, Joao" uniqKey="Rijo J" first="João" last="Rijo">João Rijo</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Povoa, Pedro" sort="Povoa, Pedro" uniqKey="Povoa P" first="Pedro" last="Povoa">Pedro Povoa</name><affiliation wicri:level="1"><nlm:affiliation>Polyvalent Intensive Care Unit, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Polyvalent Intensive Care Unit, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Pais Martins, Antonio" sort="Pais Martins, Antonio" uniqKey="Pais Martins A" first="Antonio" last="Pais Martins">Antonio Pais Martins</name><affiliation wicri:level="1"><nlm:affiliation>Surgical Intensive Care Unit. Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Surgical Intensive Care Unit. Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Carmo, Eduarda" sort="Carmo, Eduarda" uniqKey="Carmo E" first="Eduarda" last="Carmo">Eduarda Carmo</name><affiliation wicri:level="1"><nlm:affiliation>Polyvalent Intensive Care Unit. Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Polyvalent Intensive Care Unit. Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Mansinho, Kamal" sort="Mansinho, Kamal" uniqKey="Mansinho K" first="Kamal" last="Mansinho">Kamal Mansinho</name><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Fonseca, Candida" sort="Fonseca, Candida" uniqKey="Fonseca C" first="Candida" last="Fonseca">Candida Fonseca</name><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Campos, Luis" sort="Campos, Luis" uniqKey="Campos L" first="Luis" last="Campos">Luis Campos</name><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Carvalho, Ant Nio" sort="Carvalho, Ant Nio" uniqKey="Carvalho A" first="Ant Nio" last="Carvalho">Ant Nio Carvalho</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Mirco, Ana" sort="Mirco, Ana" uniqKey="Mirco A" first="Ana" last="Mirco">Ana Mirco</name><affiliation wicri:level="1"><nlm:affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Farinha, Helena" sort="Farinha, Helena" uniqKey="Farinha H" first="Helena" last="Farinha">Helena Farinha</name><affiliation wicri:level="1"><nlm:affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Aldir, Isabel" sort="Aldir, Isabel" uniqKey="Aldir I" first="Isabel" last="Aldir">Isabel Aldir</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author><author><name sortKey="Correia, Jose" sort="Correia, Jose" uniqKey="Correia J" first="José" last="Correia">José Correia</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon</wicri:regionArea><wicri:noRegion>Lisbon</wicri:noRegion></affiliation></author></analytic><series><title level="j">European journal of hospital pharmacy : science and practice</title><idno type="ISSN">2047-9956</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b></p><p>Since the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pressure to minimise its impact on public health has led to the implementation of different therapeutic strategies, the efficacy of which for the treatment of coronavirus disease 2019 (COVID-19) was unknown at the time. Remdesivir (REM) was granted its first conditional marketing authorisation in the EU in June 2020. The European Medicines Agency (EMA) and local health authorities all across the EU have since strongly recommended the implementation of pharmacovigilance activities aimed at further evaluating the safety of this new drug. The objective of this study was to evaluate adverse drug reactions (ADRs) attributed to either REM or hydroxychloroquine (HCQ) in patients hospitalised for COVID-19 in Centro Hospitalar de Lisboa Ocidental, a Portuguese hospital centre based in Lisbon. We present the preliminary results reporting plausible adverse effects of either HCQ or REM.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>An observational cohort study was carried out between 16 March and 15 August 2020. Participants were divided into two cohorts: those prescribed an HCQ regimen, and those prescribed REM. Suspected ADRs were identified using an active monitoring model and reported to the Portuguese Pharmacovigilance System through its online notification tool. The ADR cumulative incidence was compared between the two cohorts.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The study included 149 patients, of whom 101 were treated with HCQ and the remaining 48 with REM. The baseline characteristics were similar between the two cohorts. A total of 102 ADRs were identified during the study period, with a greater incidence in the HCQ cohort compared with the REM cohort (47.5% vs 12.5%; p<0.001). Causality was assessed in 81 ADRs, all of which were considered possible.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Real-world data are crucial to further establish the safety profile for REM. HCQ is no longer recommended for the treatment of COVID-19.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">33452110</PMID><DateRevised><Year>2021</Year><Month>01</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2047-9956</ISSN><JournalIssue CitedMedium="Print"><PubDate><Year>2021</Year><Month>Jan</Month><Day>15</Day></PubDate></JournalIssue><Title>European journal of hospital pharmacy : science and practice</Title><ISOAbbreviation>Eur J Hosp Pharm</ISOAbbreviation></Journal><ArticleTitle>A prospective, observational study to evaluate adverse drug reactions in patients with COVID-19 treated with remdesivir or hydroxychloroquine: a preliminary report.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ejhpharm-2020-002613</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1136/ejhpharm-2020-002613</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Since the outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pressure to minimise its impact on public health has led to the implementation of different therapeutic strategies, the efficacy of which for the treatment of coronavirus disease 2019 (COVID-19) was unknown at the time. Remdesivir (REM) was granted its first conditional marketing authorisation in the EU in June 2020. The European Medicines Agency (EMA) and local health authorities all across the EU have since strongly recommended the implementation of pharmacovigilance activities aimed at further evaluating the safety of this new drug. The objective of this study was to evaluate adverse drug reactions (ADRs) attributed to either REM or hydroxychloroquine (HCQ) in patients hospitalised for COVID-19 in Centro Hospitalar de Lisboa Ocidental, a Portuguese hospital centre based in Lisbon. We present the preliminary results reporting plausible adverse effects of either HCQ or REM.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">An observational cohort study was carried out between 16 March and 15 August 2020. Participants were divided into two cohorts: those prescribed an HCQ regimen, and those prescribed REM. Suspected ADRs were identified using an active monitoring model and reported to the Portuguese Pharmacovigilance System through its online notification tool. The ADR cumulative incidence was compared between the two cohorts.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The study included 149 patients, of whom 101 were treated with HCQ and the remaining 48 with REM. The baseline characteristics were similar between the two cohorts. A total of 102 ADRs were identified during the study period, with a greater incidence in the HCQ cohort compared with the REM cohort (47.5% vs 12.5%; p<0.001). Causality was assessed in 81 ADRs, all of which were considered possible.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Real-world data are crucial to further establish the safety profile for REM. HCQ is no longer recommended for the treatment of COVID-19.</AbstractText><CopyrightInformation>© European Association of Hospital Pharmacists 2021. No commercial re-use. See rights and permissions. Published by BMJ.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Falcão</LastName><ForeName>Fátima</ForeName><Initials>F</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2860-061X</Identifier><AffiliationInfo><Affiliation>Pharmacy, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal mffalcao@chlo.min-saude.pt.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viegas</LastName><ForeName>Erica</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carmo</LastName><ForeName>Ines</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soares</LastName><ForeName>Joana</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falcao</LastName><ForeName>Margarida</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Solano</LastName><ForeName>Mariana</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cavaco</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mendes</LastName><ForeName>Dina</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rijo</LastName><ForeName>João</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Povoa</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Polyvalent Intensive Care Unit, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pais Martins</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Surgical Intensive Care Unit. Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carmo</LastName><ForeName>Eduarda</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Polyvalent Intensive Care Unit. Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mansinho</LastName><ForeName>Kamal</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fonseca</LastName><ForeName>Candida</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campos</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carvalho</LastName><ForeName>António</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Internal Medicine, Hospital de S. Francisco Xavier, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mirco</LastName><ForeName>Ana</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farinha</LastName><ForeName>Helena</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Social Pharmacy, Universidade de Lisboa Faculdade de Farmácia, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Pharmacy Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aldir</LastName><ForeName>Isabel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Infecciology Department, Hospital de Egas Moniz, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Correia</LastName><ForeName>José</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Pharmacy and Therapeutics Committee, Centro Hospitalar de Lisboa Ocidental EPE, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2021</Year><Month>01</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Eur J Hosp Pharm</MedlineTA><NlmUniqueID>101578294</NlmUniqueID><ISSNLinking>2047-9956</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">clinical medicine</Keyword><Keyword MajorTopicYN="N">drug monitoring</Keyword><Keyword MajorTopicYN="N">drug-related side effects and adverse reactions</Keyword><Keyword MajorTopicYN="N">hospital</Keyword><Keyword MajorTopicYN="N">pharmacy service</Keyword></KeywordList><CoiStatement>Competing interests: None declared.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>11</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>12</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2021</Year><Month>01</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2021</Year><Month>1</Month><Day>16</Day><Hour>5</Hour><Minute>32</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2021</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>1</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33452110</ArticleId><ArticleId IdType="pii">ejhpharm-2020-002613</ArticleId><ArticleId IdType="doi">10.1136/ejhpharm-2020-002613</ArticleId><ArticleId IdType="pmc">PMC7813046</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Eur J Hosp Pharm. 2020 Jul;27(4):191-193</Citation><ArticleIdList><ArticleId IdType="pubmed">32587077</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Aug 6;383(6):517-525</Citation><ArticleIdList><ArticleId IdType="pubmed">32492293</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Pharmacol Ther. 2020 Oct;108(4):791-797</Citation><ArticleIdList><ArticleId IdType="pubmed">32324898</ArticleId></ArticleIdList></Reference><Reference><Citation>Therapie. 2020 Jul - Aug;75(4):371-379</Citation><ArticleIdList><ArticleId IdType="pubmed">32418730</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Nov 19;383(21):2030-2040</Citation><ArticleIdList><ArticleId IdType="pubmed">33031652</ArticleId></ArticleIdList></Reference><Reference><Citation>Ophthalmology. 2016 Jun;123(6):1386-94</Citation><ArticleIdList><ArticleId IdType="pubmed">26992838</ArticleId></ArticleIdList></Reference><Reference><Citation>Obesity (Silver Spring). 2020 Jul;28(7):1195-1199</Citation><ArticleIdList><ArticleId IdType="pubmed">32271993</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 May 12;323(18):1824-1836</Citation><ArticleIdList><ArticleId IdType="pubmed">32282022</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Nov 5;383(19):1813-1826</Citation><ArticleIdList><ArticleId IdType="pubmed">32445440</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Jun 11;382(24):2327-2336</Citation><ArticleIdList><ArticleId IdType="pubmed">32275812</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Clin Microbiol Infect Dis. 2020 Sep;39(9):1629-1635</Citation><ArticleIdList><ArticleId IdType="pubmed">32333222</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Immunol. 2020 Aug 11;11:1991</Citation><ArticleIdList><ArticleId IdType="pubmed">32903476</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 May 7;382(19):1787-1799</Citation><ArticleIdList><ArticleId IdType="pubmed">32187464</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Obes. 2020 Dec;10(6):e12403</Citation><ArticleIdList><ArticleId IdType="pubmed">32857454</ArticleId></ArticleIdList></Reference><Reference><Citation>Obes Rev. 2020 Jun;21(6):e13034</Citation><ArticleIdList><ArticleId IdType="pubmed">32281287</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Portugal</li></country></list><tree><country name="Portugal"><noRegion><name sortKey="Falcao, Fatima" sort="Falcao, Fatima" uniqKey="Falcao F" first="Fátima" last="Falcão">Fátima Falcão</name></noRegion><name sortKey="Aldir, Isabel" sort="Aldir, Isabel" uniqKey="Aldir I" first="Isabel" last="Aldir">Isabel Aldir</name><name sortKey="Aldir, Isabel" sort="Aldir, Isabel" uniqKey="Aldir I" first="Isabel" last="Aldir">Isabel Aldir</name><name sortKey="Aldir, Isabel" sort="Aldir, Isabel" uniqKey="Aldir I" first="Isabel" last="Aldir">Isabel Aldir</name><name sortKey="Campos, Luis" sort="Campos, Luis" uniqKey="Campos L" first="Luis" last="Campos">Luis Campos</name><name sortKey="Campos, Luis" sort="Campos, Luis" uniqKey="Campos L" first="Luis" last="Campos">Luis Campos</name><name sortKey="Carmo, Eduarda" sort="Carmo, Eduarda" uniqKey="Carmo E" first="Eduarda" last="Carmo">Eduarda Carmo</name><name sortKey="Carmo, Ines" sort="Carmo, Ines" uniqKey="Carmo I" first="Ines" last="Carmo">Ines Carmo</name><name sortKey="Carvalho, Ant Nio" sort="Carvalho, Ant Nio" uniqKey="Carvalho A" first="Ant Nio" last="Carvalho">Ant Nio Carvalho</name><name sortKey="Carvalho, Ant Nio" sort="Carvalho, Ant Nio" uniqKey="Carvalho A" first="Ant Nio" last="Carvalho">Ant Nio Carvalho</name><name sortKey="Cavaco, Patricia" sort="Cavaco, Patricia" uniqKey="Cavaco P" first="Patricia" last="Cavaco">Patricia Cavaco</name><name sortKey="Correia, Jose" sort="Correia, Jose" uniqKey="Correia J" first="José" last="Correia">José Correia</name><name sortKey="Falcao, Fatima" sort="Falcao, Fatima" uniqKey="Falcao F" first="Fátima" last="Falcão">Fátima Falcão</name><name sortKey="Falcao, Fatima" sort="Falcao, Fatima" uniqKey="Falcao F" first="Fátima" last="Falcão">Fátima Falcão</name><name sortKey="Falcao, Margarida" sort="Falcao, Margarida" uniqKey="Falcao M" first="Margarida" last="Falcao">Margarida Falcao</name><name sortKey="Farinha, Helena" sort="Farinha, Helena" uniqKey="Farinha H" first="Helena" last="Farinha">Helena Farinha</name><name sortKey="Farinha, Helena" sort="Farinha, Helena" uniqKey="Farinha H" first="Helena" last="Farinha">Helena Farinha</name><name sortKey="Farinha, Helena" sort="Farinha, Helena" uniqKey="Farinha H" first="Helena" last="Farinha">Helena Farinha</name><name sortKey="Fonseca, Candida" sort="Fonseca, Candida" uniqKey="Fonseca C" first="Candida" last="Fonseca">Candida Fonseca</name><name sortKey="Fonseca, Candida" sort="Fonseca, Candida" uniqKey="Fonseca C" first="Candida" last="Fonseca">Candida Fonseca</name><name sortKey="Mansinho, Kamal" sort="Mansinho, Kamal" uniqKey="Mansinho K" first="Kamal" last="Mansinho">Kamal Mansinho</name><name sortKey="Mansinho, Kamal" sort="Mansinho, Kamal" uniqKey="Mansinho K" first="Kamal" last="Mansinho">Kamal Mansinho</name><name sortKey="Mendes, Dina" sort="Mendes, Dina" uniqKey="Mendes D" first="Dina" last="Mendes">Dina Mendes</name><name sortKey="Mirco, Ana" sort="Mirco, Ana" uniqKey="Mirco A" first="Ana" last="Mirco">Ana Mirco</name><name sortKey="Mirco, Ana" sort="Mirco, Ana" uniqKey="Mirco A" first="Ana" last="Mirco">Ana Mirco</name><name sortKey="Pais Martins, Antonio" sort="Pais Martins, Antonio" uniqKey="Pais Martins A" first="Antonio" last="Pais Martins">Antonio Pais Martins</name><name sortKey="Povoa, Pedro" sort="Povoa, Pedro" uniqKey="Povoa P" first="Pedro" last="Povoa">Pedro Povoa</name><name sortKey="Povoa, Pedro" sort="Povoa, Pedro" uniqKey="Povoa P" first="Pedro" last="Povoa">Pedro Povoa</name><name sortKey="Rijo, Joao" sort="Rijo, Joao" uniqKey="Rijo J" first="João" last="Rijo">João Rijo</name><name sortKey="Soares, Joana" sort="Soares, Joana" uniqKey="Soares J" first="Joana" last="Soares">Joana Soares</name><name sortKey="Solano, Mariana" sort="Solano, Mariana" uniqKey="Solano M" first="Mariana" last="Solano">Mariana Solano</name><name sortKey="Viegas, Erica" sort="Viegas, Erica" uniqKey="Viegas E" first="Erica" last="Viegas">Erica Viegas</name><name sortKey="Viegas, Erica" sort="Viegas, Erica" uniqKey="Viegas E" first="Erica" last="Viegas">Erica Viegas</name><name sortKey="Viegas, Erica" sort="Viegas, Erica" uniqKey="Viegas E" first="Erica" last="Viegas">Erica Viegas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidChloroV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000763 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000763 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidChloroV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:33452110
|texte= A prospective, observational study to evaluate adverse drug reactions in patients with COVID-19 treated with remdesivir or hydroxychloroquine: a preliminary report.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:33452110" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidChloroV1
| This area was generated with Dilib version V0.6.38. |  |